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Rare Genetic Diseases: Providing more effective therapeutic proteins for treatment of a host of conditions

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Glycoconjugates – glycans linked with proteins, lipids, or other molecules – are a crucial component of many therapeutics, including protein-based drugs and vaccines targeting microbial pathogens. The innate immune system detects proteins and pathogens via their non-host surface glycans, leading to the activation of an immune response and a clearance of these molecules from the body. In this theme we will advance approaches in this area to develop new therapeutic proteins and vaccines for a host of conditions.