ProfileProfessor Robert Britton obtained his B. Sc. from the University of Waterloo in 1996 working with Professor Victor Snieckus, and his Ph. D. in natural product isolation, structural elucidation, and total synthesis from the University of British Columbia under the supervision of Professors Edward Piers and Raymond Anderson. He spent two years at the University of Cambridge with Professor Ian Paterson as an NSERC PDF then joined the Process Research Group at Merck as a Senior Scientist before starting an independent career at Simon Fraser University in 2005. He is a Michael Smith Foundation for Health Research Career Scholar and his research program focuses on the concise synthesis of structurally and stereochemically complex natural products and the discovery of new synthetic methods to support drug discovery and development.
GlycoNet Funded ProjectsProducts
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Synthesis of the Campylobacter jejuni 81-176 strain capsular polysaccharide repeating unit reveals the absolute configuration of its O-methyl phosphoramidate motifSD-1 University of Alberta | Publication | 2018-10-01 | | Application of Sequential Proline Catalyzed ?-Chlorination and Aldol Reactions in the Total Synthesis of 1-Deoxygalactonojirimycin Simon Fraser University | Publication | 2018-01-01 | | Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives University of British Columbia, Simon Fraser University | Publication | 2018-01-01 | Michael Meanwell, Bharani Shashank Adluri, Zheliang Yuan, Josiah Newton, Philippe Prevost, Matthew B. Nodwell, Chadron M. Friesen, Paul Schaffer, Rainer E. Martin, Robert Britton | Synthesis of Acyl Fluorides via Photocatalytic Fluorination of Aldehydic C-H Bonds Simon Fraser University | Publication | 2018-01-01 | Michael Meanwell, Marc Eichenberger, Johannes Lehmann, Matthew B. Nodwell, Rainer E. Martin(CA), Robert Britton | Synthesis of Heterobenzylic Fluorides Simon Fraser University | Publication | 2018-01-01 | | A Convenient Late-Stage Fluorinationof Pyridylic C-H Bonds with N-Fluorobenzenesulfonimide Simon Fraser University | Publication | 2016-01-01 | Michael Meanwell, Matthew B. Nodwell, Rainer E. Martin, Robert Britton | Quaternary Ammonium TrifluoromethoxideSalts as Stable Sources of Nucleophilic OCF3 Simon Fraser University | Publication | 2020-01-01 | J Newton J , B J Jelier, Michael Meanwell, R E Martin, Robert Britton, "Chadron M. Frieson " | Alpha-Arylation and Ring Expansion of Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones Simon Fraser University | Publication | 2016-01-01 | Chang Stanley, Michael Holmes, Jeffrey Mowat, Michael Meanwell, Robert Britton | Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2) (featured as a Hot Article) Simon Fraser University | Publication | 2016-01-01 | E. Martin(CA) Rainer, Johannes Lehmann, Thibaut Alzieu, Mario Lenz, Marjorie A. Carnero Corrales, Johannes D. Aebi, Hans Peter Märki, Bernd Kuhn, Kurt Amrein, Alexander V. Mayweg, Robert Britton | Base-Catalyzed Transesterification of Thionoesters Simon Fraser University | Publication | 2018-01-01 | | A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A Simon Fraser University | Publication | 2019-01-01 | Y. S. Lam Nelson, Garrett Muir, Venugopal Rao Challa, Robert Britton, Ian Paterson(CA) | Common bed bugs biosynthesize pheromone components from aminoacid precursors in human blood Simon Fraser University | Publication | 2018-01-01 | Gries Regine, Huimin Zhai, Andrew R. Lewis, Robert Britton, Gerhard Gries(CA) | Total Synthesis, Stereochemical Assignment, and Field-Testing of the Sex Pheromone of the Strepsipteran Xenos peckii (Featured on the Back Cover) Simon Fraser University | Publication | 2016-01-01 | Zhai Huimin, Michael Hrabar, Regine Gries, Gerhard Gries(CA), Robert Britton | A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters using Silver(I) Fluoride University of British Columbia, Simon Fraser University | Publication | 2019-01-01 | | Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from DolichovespulaYellowjackets Simon Fraser University | Publication | 2019-01-01 | Weiwu Ren, Regine Gries, Kenji L. Kurita, Catherine S. McCaughey, Santosh K. Alamsetti, Roger G. Linington (CA), Gerhard Gries (CA), Robert Britton | Structural and Functional Insight into Human O-GlcNAcase Simon Fraser University | Publication | 2017-01-01 | Roth Christian, Sherry Chan, Wendy Offen, Glyn Hemsworth, Lianne Willems, Dustin King, Vimal Varghese, Robert Britton, David Vocadlo, Gideon Davies(CA) | Maculatic acids - sex attractant pheromone components of bald-faced hornets Simon Fraser University | Publication | 2018-06-01 | Weiwu Ren, Regine Gries, Catherine McCaughey, Nathan Derstine, Santosh Alamsetti, Kenji Kurita, Lorna Tu, Roger Linington, Robert Britton, Gerhard J Gries | Bis-acetalfluorescence-quenched substrates for quantitative monitoring of endogenousa-galactosidase and a-galactosaminidase activity in live patient cellsCD-35 University of Montreal, Simon Fraser University | Publication | 2020-01-01 | Samy Cecioni, R A Ashmus, P -A Gilormini, Sha Zhu, Xiaoyang Shan, Christina Gros, Matthew Deen, Yang Wang, Robert Britton, D J Vocadlo(CA) | Site-Selective, Late-Stage C-H 18F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging University of British Columbia, Simon Fraser University | Publication | 2018-01-01 | Yuan Zheliang, Matthew B. Nodwell, Hua Yang, Noeen Malik, Helen Merkins, Francois Benard, Rainer E. Martin, Paul Schaffer, Robert Britton | Maculatic acids – sex attractant pheromone components of bald-faced hornets (featured as Cover Picture) Simon Fraser University | Publication | 2018-01-01 | Weiwu Ren, Regine Gries, Catherine Mccaugh, Nathan Derstine, Santosh K. Alamsetti, Kenji Kurita, Lorna Tu, Roger Linington(CA), Robert Britton, Gerhard Gries(CA) | 18F-Fluorination of Unactivated C-H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents University of British Columbia, Simon Fraser University | Publication | 2017-01-01 | B. Nodwell Matthew, Hua Yang, Milena Colovic, Zheliang Yuan, Helen Merkens, Rainer E. Martin, François Bénard, Paul Schaffer, Robert Britton | Synergism of anisotropic and computational NMR methodsreveals the likely configuration of phormidolide A Simon Fraser University | Publication | 2020-01-01 | E Ndukwe Ikenna, Xiao Wang, Nelson Y S Lam, Kristaps Ermanis, Kelsey L Alexander, Matthew Bertin, Gary E Martin, Garrett Muir, Ian Paterson, Robert Britton, Jonathan M Goodman, Eric J N Helfrich, Jörn Piel, "William H. Gerwick ", "R. Thomas Williamson " | 18F-branched chain amino acids: structure-activity relationships and PET imaging potential University of British Columbia, Simon Fraser University | Publication | 2019-01-01 | B. Nodwell Matthew, Hua Yang, Helen Merkens, Noeen Malik, Milena Colovic, Bjorn Wagner, Rainer E. Martin, François Bénard, Paul Schaffer, Robert Britton | Electrostatic Effects Accelerate Decatungstate-Catalyzed C–H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics University of British Columbia, Simon Fraser University | Publication | 2019-01-01 | Yuan Zheliang, Hua Yang, Noeen Malik, Milena Čolović, David S. Weber, Darryl Wilson, François Bénard, Rainer E. Martin, Jeffrey J. Warren, Paul Schaffer, Robert Britton |
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