| Proximity Ligation-Based Fluorogenic Imaging Agents for Neuraminidases Scripps Research Institute, University of British Columbia | Publication | 2018-09-01 | |
| The effect of interleukin-8 truncations on its interactions with glycosaminoglycans | Publication | 2018-01-01 | Karoline Nordsieck, Lars Baumann, Vera Hintze, M Teresa Pisabarro, Matthias Schnabelrauch, Annette G Beck-Sickinger, Sergey A Samsonov |
| Directed evolution of bacterial polysialyltransferase for in vitro synthesis of polySia.Polysialic acid (polySia) is s natural polymer found on a handful of eukaryotic proteins, and bacterial capsular polysaccharides. The enzymatic addition of polySia, to existing glycans on a therapeutic protein can increase the serum half-life of the protein, improving the efficacy of treatment. The enzymes that have been used for this process (PolySTs) come from bacterial pathogens such as Mannheimia haemolytica serotype A2, Neisseria meningitidis group B, and Escherichia coli K1.
PolySTs are membrane-associated proteins and suffer from inherently low solubility, low expression levels and/or thermal instability. To improve their physicochemical and biochemical properties, we developed a directed evolution approach using a FACS-based ultrahigh-throughput assay in combination with a secondary screen using a micro titre plate-based assay to assess activity from the enriched mutant pool directly on a protein substrate. We will present the results for mutants we found which show better synthetic properties than the wild type enzyme. TP-2 University of British Columbia, Ryerson University | Presentation | 2018-05-11 | |
| Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid a-glycosyltransferase University of British Columbia | Publication | 2015-01-01 | Solmaz Sobhanifar, Worrall* LJ, Gruninger* RJ, Wasney GA*, Blaukopf M, Lars Baumann, Lameignere* E, Solomonson M*, Brown ED, Stephen G. Withers, Natalie Strynadka |
| Prospecting for microbial alpha-N-acetylgalactosaminidases yields a new class of GH 31 O-glycanaseTP-1 University of British Columbia | Publication | 2019-09-01 | Peter Rahfeld, Jacob Wardman, Kevin Mehr, Drew Huff, Connor Morgan-Lang, Hong-Ming Chen, Steven J Hallam, Stephen G. Withers |
| A mechanism based approach to screening metagenomic libraries for discovery of unconventional glycosidases University of British Columbia | Publication | 2018-07-01 | |
| Synthesis and evaluation of a series of 6-chloro-4-methylumbelliferyl glycosides as fluorogenic reagents for screening metagenomic libraries for glycosidase activity University of British Columbia | Publication | 2016-02-01 | |
| Synthesis of azido-deoxy and amino-deoxy glycosides and glycosyl fluorides for screening of glycosidase libraries and assembly of substituted glycosides University of British Columbia | Publication | 2018-09-01 | |
| Catalytic properties of a mutant beta-galactosidase from Xanthomonas manihotis engineered to synthesize galactosyl-thio-beta-1,3 and -beta-1,4-glycosides. University of British Columbia | Publication | 2006-08-01 | |
| Enzymatic transglycosylation of xylose using a glycosynthase. University of British Columbia | Publication | 2005-12-01 | |
| Thioglycosynthases: double mutant glycosidases that serve as scaffolds for thioglycoside synthesis. University of British Columbia | Publication | 2004-02-01 | |
| O-glycoligases, a new category of glycoside bond-forming mutant glycosidases, catalyse facile syntheses of isoprimeverosides University of British Columbia | Publication | 2010-12-01 | |
| Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex. University of British Columbia | Publication | 2006-02-01 | |
| Modulating the nucleophile of a glycoside hydrolase through site-specific incorporation of fluoroglutamic acids University of British Columbia | Publication | 2018-06-01 | Miriam P Koetzler, Kyle Robinson, Hong-Ming Chen, Mark Okon, Lawrence P McIntosh, Stephen G. Withers |
| Facile formation of beta-thioGlcNAc linkages to thiol-containing sugars, peptides, and proteins using a mutant GH20 hexosaminidaseTP-1 University of British Columbia, Concordia University | Publication | 2018-12-01 | |
| Glucosyl Epi-cyclophellitol Allows Mechanism- Based Inactivation and Structural Analysis of Human Pancreatic Alpha-AmylaseDO-2 University of British Columbia | Publication | 2016-03-18 | Sami Caner, Xiaohua Zhang, "Jiang, J ", Hong-Ming Chen, "Nguyen, N T ", Hermen Overkleeft, Gary Brayer, Stephen G. Withers |
| REMARKABLE REACTIVITY DIFFERENCES BETWEEN GLUCOSIDES WITH IDENTICAL LEAVING GROUPSTP-1 University of British Columbia | Publication | 2017-10-01 | Tianmeng Duo, Kyle Robinson, Ian R Greig, Hong-Ming Chen, Brian O Patrick, Stephen G. Withers |
| Oversized galactosides as a probe for conformational dynamics in LacYTP-1, TP-2 University of British Columbia | Publication | 2018-03-20 | |
| High-Throughput Recovery and Characterization of Metagenome-Derived Glycoside Hydrolase-Containing Clones as a Resource for Biocatalyst DevelopmentTP-1 University of British Columbia | Publication | 2019-06-01 | Zachary Armstrong, Feng Liu, Sam Kheirandish, Hong-Ming Chen, Keith Mewis, Tianmeng Duo, Connor Morgan-Lang, Steven J Hallam, Stephen G. Withers |
| Observing cellulose biosynthesis and membrane translocation in crystalloAM-5 University of British Columbia | Publication | 2016-04-15 | Jacob L. W. Morgan, Joshua T. McNamara, Michael Fischer, Jamie Rich, Hong-Ming Chen, Stephen G. Withers, Jochen Zimmer |
| High-throughput screening methodology for the directed evolution of glycosyltransferases. University of British Columbia, University of Alberta | Publication | 2006-08-01 | |
| Rationally Designed Short Polyisoprenol-Linked PglB Substrates for Engineered Polypeptide and Protein N-Glycosylation | Publication | 2013-12-01 | Feng Liu, Balakumar Vijayakrishnan, Amirreza Faridmoayer, Thomas A. Taylor, Thomas B. Parsons, Gonç alo J.L. Bernardes, Michael Kowarik, Benjamin G. Davis |
| PseG of Pseudaminic Acid Biosynthesis | Publication | 2006-05-01 | Feng Liu, Martin E. Tanner |
| The Engineering of Bacteria Bearing Azido-Pseudaminic Acid-Modified Flagella | Publication | 2009-05-01 | Feng Liu, Annie J. Aubry, Ian C. Schoenhofen, Susan M. Logan, Martin E. Tanner |
| Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH 107) display structural and mechanistic similarities to alpha-L-fucosidases from GH29 University of British Columbia, University of Victoria | Publication | 2018-10-01 | |
| Metagenomics reveals functional synergy and novel polysaccharide utilization loci in the Castor canadensis fecal microbiome University of British Columbia | Publication | 2018-07-01 | Zachary Armstrong, Keith Mewis, Feng Liu, Connor Morgan-Lang, Melanie Scofield, Evan Durno, Hong Ming Chen, Kevin Mehr, Stephen G. Withers, Steven J Hallam |
| The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme University of British Columbia, University of Victoria | Publication | 2018-04-01 | |
| Glycobiology: The case of the missing base University of British Columbia | Publication | 2012-12-01 | |
| One step closer to a sweet conclusion. University of British Columbia, University of Alberta | Publication | 2002-12-01 | |
| Novel Glycosidase Inhibition Motifs Found in AmylaseDO-2 University of British Columbia | Publication | 2015-12-15 | Stephen G. Withers, Gary Brayer, "Andersen R ", "Williams L ", "Zhang X ", Christina Tysoe, "Coleman J ", "Keyzers R ", "Mcneill J ", "Yuen V ", Sami Caner, "Nguyen N " |
| Seminar at Univ. of Saskatchewan on "Discovery, design and development of human amylase inhibitors: from nM to pM"Departmental Seminar at Univ of Saskatchewan entitled "Discovery, design and development of human amylase inhibitors: from nM to pM"DO-2, DO-6 University of British Columbia | Presentation | 2018-02-28 | |
| Discovery and characterisation of novel glycoenzymes for glycoside synthesis and antigen removal using metagenomic screens. Invited lecture at ABC CancunInvited lecture at the International ABC Chem in CancunTP-1, TP-2 University of British Columbia | Presentation | 2018-01-24 | |
| Discovery, design and development of human amylase inhibitors: from nM to pMInvited lecture at ALAMY conference in Smolenice Castle, BratislavaDO-2 University of British Columbia | Presentation | 2019-09-28 | |
| How to make a difference: mechanisms of protein and nucleic acid modifying enzymes Simon Fraser University, University of British Columbia | Publication | 2012-12-01 | |
| Detailed comparative analysis of the catalytic mechanisms of beta-N-acetylglucosaminidases from families 3 and 20 of glycoside hydrolases. Simon Fraser University, University of British Columbia | Publication | 2005-09-01 | |
| The chemical synthesis of 2-deoxy-2-fluorodisaccharide probes of the hen egg white lysozyme mechanism. Simon Fraser University, University of British Columbia | Publication | 2005-02-01 | |
| Identification of active site residues in glycosidases by use of tandem mass spectrometry. Simon Fraser University, University of British Columbia | Publication | 2000-01-01 | |
| Phosphodiesters serve as potentially tunable aglycones for fluoro sugar inactivators of retaining β-glycosidasesRG-2 University of British Columbia | Publication | 2014-04-01 | |
| Fluorinated mechanism-based inhibitors: common themes and recent developments University of British Columbia | Publication | 2014-02-01 | |
| Unusual enzymatic glycoside cleavage mechanisms University of British Columbia | Publication | 2014-01-01 | |
| Synthesis of glycans and glycopolymers through engineered enzyme University of British Columbia | Publication | 2013-10-01 | |
| Improvement of the expression level of beta-glucosidase from Agrobacterium sp. in Escherichia coli by rare codon optimization University of British Columbia | Publication | 2013-02-01 | |
| Identification of Tyr241 as a key catalytic base in the family 4 glycoside hydrolase BglT from Thermotoga maritima. University of British Columbia | Publication | 2012-10-01 | |
| A chemoenzymatic total synthesis of the neurogenic starfish ganglioside LLG-3 using an engineered and evolved synthase University of British Columbia | Publication | 2012-08-01 | |
| Natural product biosynthesis: Tackling tunicamycin University of British Columbia | Publication | 2012-07-01 | |
| The role of the oligosaccharide binding cleft of rice BGlu1 in hydrolysis of cellooligosaccharides and in their synthesis by rice BGlu1 glycosynthase University of British Columbia | Publication | 2012-03-01 | |
| Glycoside cleavage by a new mechanism in unsaturated glucuronyl hydrolases University of British Columbia | Publication | 2011-12-01 | |
| Syntheses of p-nitrophenyl 3- and 4-thio-beta-D-glycopyranosides University of British Columbia | Publication | 2010-12-01 | |
| New approaches to enzymatic glycoside synthesis through directed evolution University of British Columbia | Publication | 2010-07-01 | |
| Chemoenzymatic synthesis and enzymatic analysis of 8-modified cytidine monophosphate-sialic acid and sialyl lactose derivatives University of British Columbia | Publication | 2010-07-01 | |
| Ultrahigh-throughput FACS-based screening for directed enzyme evolution University of British Columbia | Publication | 2009-11-01 | |
| Recent developments in glycoside synthesis with glycosynthases and thioglycoligases University of British Columbia | Publication | 2009-06-01 | |
| Non-Stick sugars: synthesis of difluorosugar fluorides as potential glycosidase inactivators University of British Columbia | Publication | 2009-06-01 | |
| The chitopentaose complex of a mutant hen-egg white lysozyme displays no distortion of the –1 sugar away from a 4C1 chair conformation University of British Columbia, Simon Fraser University | Publication | 2009-06-01 | |
| Emerging methods for the production of homogeneous human glycoproteins. University of British Columbia | Publication | 2009-04-01 | |
| Covalent inhibitors of glycosidases and their applications in biochemistry and biology. University of British Columbia | Publication | 2008-08-01 | |
| Nature teaches but can be bettered. University of British Columbia | Publication | 2008-04-01 | |
| Teaching old enzymes new tricks: engineering and evolution of glycosidases and glycosyl transferases for improved glycoside synthesis. University of British Columbia | Publication | 2008-04-01 | |
| Syntheses of the 3- and 4-thio analogues of 4-nitrophenyl 2-acetamido-2-deoxy-beta-D-gluco- and galactopyranoside. University of British Columbia | Publication | 2007-11-01 | |
| Enzymatic synthesis of cello-oligosaccharides by rice BGlu1 {beta}-glucosidase glycosynthase mutants. University of British Columbia | Publication | 2007-07-01 | |
| Facile synthesis of 2,4-dinitrophenyl alpha-D-glycopyranosides as chromogenic substrates for alpha-glycosidases. University of British Columbia | Publication | 2007-05-01 | |
| Towards universal red blood cells. University of British Columbia | Publication | 2007-04-01 | |
| Direct demonstration of the flexibility of the glycosylated proline-threonine linker in the Cellulomonas fimi Xylanase Cex through NMR spectroscopic analysis. University of British Columbia | Publication | 2007-01-01 | |
| Family 4 glycosidases carry out efficient hydrolysis of thioglycosides by an alpha,beta-elimination mechanism. University of British Columbia | Publication | 2006-09-01 | |
| Breakdown of oligosaccharides by the process of elimination. University of British Columbia | Publication | 2006-04-01 | |
| Mechanistic analysis of the unusual redox-elimination sequence employed by Thermotoga maritima BglT: a 6-phospho-beta-glucosidase from glycoside hydrolase family 4. University of British Columbia | Publication | 2006-01-01 | |
| Nature's many mechanisms for the degradation of oligosaccharides. University of British Columbia | Publication | 2004-10-01 | |
| Mechanistic analogies amongst carbohydrate modifying enzymes. University of British Columbia | Publication | 2004-10-01 | |
| The synthesis of a series of modified mannotrisaccharides as probes of the enzymes involved in the early stages of mammalian complex N-glycan formation. University of British Columbia | Publication | 2004-10-01 | |
| Glycosynthase-catalysed formation of modified polysaccharide microstructures . University of British Columbia | Publication | 2004-06-01 | |
| The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases. University of British Columbia | Publication | 2004-02-01 | |
| Toward Efficient Enzymatic Glycan Synthesis: Directed Evolution and Enzyme Engineering University of British Columbia | Publication | 2011-01-01 | |
| Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic $\upalpha$-AmylaseDO-2 University of British Columbia | Publication | 2018-09-01 | |
| Identity and role of the non-Conserved Acid/Base Catalytic residue in the GH 29 fucosidase from the spider Nephilingis cruentata University of British Columbia | Publication | 2018-09-01 | |
| Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. University of British Columbia | Publication | 2008-09-01 | |
| Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. University of British Columbia | Publication | 2003-11-01 | |
| Trapping covalent intermediates on beta-glycosidases. University of British Columbia | Publication | 2002-01-01 | |
| Role of beta Arg211 in the active site of human beta-hexosaminidase B. Simon Fraser University, University of British Columbia | Publication | 2000-05-01 | |
| High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. University of British Columbia | Publication | 2007-02-01 | |
| A homology model for human alpha-l-iduronidase: insights into human disease. University of British Columbia | Publication | 2005-05-01 | |
| Fluoro-glycosyl acridinones are ultra-sensitive active site titrating agents for retaining β-glycosidases University of British Columbia | Publication | 2014-07-01 | |
| Mechanistic investigations of unsaturated glucuronyl hydrolase from Clostridium perfringens University of British Columbia | Publication | 2014-04-01 | |
| Mechanistic insights from substrate preference in unsaturated glucuronyl hydrolase University of British Columbia | Publication | 2014-01-01 | |
| Rice BGlu1 glycosynthase and wild type transglycosylation activities distinguished by cyclophellitol inhibition. University of British Columbia | Publication | 2012-05-01 | |
| Stereoselective total synthesis of aminoiminohexitols via carbamate annulation University of British Columbia | Publication | 2011-12-01 | |
| Molecular probes: Getting lucky in the lysosome University of British Columbia | Publication | 2010-12-01 | |
| Mechanistic analysis of the blood group antigen-cleaving endo-beta-galactosidase from Clostridium perfringens University of British Columbia | Publication | 2009-09-01 | |
| Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis. University of British Columbia | Publication | 2009-05-01 | |
| Elucidating the nature of the Streptomyces plicatus beta-hexosaminidase-bound intermediate using ab initio molecular dynamics simulations. University of British Columbia | Publication | 2008-12-01 | |
| High-throughput screening of cell lysates for ganglioside synthesis. University of British Columbia | Publication | 2008-11-01 | |
| A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors. University of British Columbia | Publication | 2008-01-01 | |
| Mechanism of GlvA from Bacillus subtilis: a detailed kinetic analysis of a 6-phospho-alpha-glucosidase from glycoside hydrolase family 4. University of British Columbia | Publication | 2007-08-01 | |
| Conformational changes induced by binding UDP-2F-galactose to alpha-1,3 galactosyltransferase- implications for catalysis. University of British Columbia | Publication | 2007-06-01 | |
| Transition-state mimicry by glycosidase inhibitors: a critical kinetic analysis. University of British Columbia | Publication | 2007-04-01 | |
| Alternative donor substrates for inverting and retaining glycosyltransferases. University of Alberta, University of British Columbia | Publication | 2007-01-01 | |
| Engineering of glycosidases and glycosyltransferases. University of British Columbia | Publication | 2006-10-01 | |
| Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase. University of British Columbia | Publication | 2006-02-01 | |
| Synthesis and testing of mechanism-based protein-profiling probes for retaining endo-glycosidases. University of British Columbia | Publication | 2006-01-01 | |
| Glucose Lowering Effect of Montbretin A in Zucker Diabetic Fatty RatsDO-2, DO-6 University of British Columbia | Publication | 2015-05-15 | V G Yuen, "J Coleman ", Stephen G. Withers, "R J Andersen ", Gary Brayer, "S Mustafa ", J H McNeil |
| The p K a values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozymeTP-1 University of British Columbia | Publication | 2018-12-01 | |
| A case for reverse protonation: identification of Glu160 as an acid/base catalyst in Thermoanaerobacterium saccharolyticum beta-xylosidase and detailed kinetic analysis of a site-directed mutant. University of California, Berkeley, University of British Columbia | Publication | 2002-08-01 | |
| Mechanism of Thermoanaerobacterium saccharolyticum beta-xylosidase: kinetic studies. University of California, Berkeley, University of British Columbia | Publication | 2002-08-01 | |
| Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate. Simon Fraser University, University of British Columbia | Publication | 2001-08-01 | |
| Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B. Simon Fraser University, University of British Columbia | Publication | 2001-02-01 | |
| Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-beta-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-alpha-L-idopyranosyl fluoride. Simon Fraser University, University of British Columbia | Publication | 2000-01-01 | |
| Assignment of selectively 13C-labeled cellopentaose synthesized using an engineered glycosynthase. Royal Institute of Technology, University of British Columbia | Publication | 2001-09-01 | |
| Identification of Asp-130 as the catalytic nucleophile in the main alpha-galactosidase from Phanerochaete chrysosporium, a family 27 glycosyl hydrolase. University of British Columbia, Royal Institute of Technology | Publication | 2000-08-01 | |
| Identifying the catalytic acid/base in GH29 α-L-fucosidase subfamilies University of British Columbia | Publication | 2013-08-01 | |
| Nuclear magnetic resonance spectral assignments of α-1,4-galactosyltransferase LgtC from Neisseria meningitidis: substrate binding and multiple conformational states University of British Columbia | Publication | 2012-10-01 | |
| Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase University of British Columbia | Publication | 2011-10-01 | |
| Tailoring the specificity and reactivity of a mechanism-based inactivator of glucocerebrosidase for potential therapeutic applications University of British Columbia | Publication | 2011-10-01 | |
| Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of beta-glucocerebrosidase University of British Columbia | Publication | 2011-09-01 | |
| Glycosynthase-mediated assembly of xylanase substrates and inhibitors University of British Columbia | Publication | 2011-07-01 | |
| Enzymatic thioxyloside synthesis: characterization of thioglycoligase variants identified from a site-saturation mutagenesis library of Bacillus circulans xylanase University of British Columbia | Publication | 2010-03-01 | |
| A mechanism-based ICAT strategy for comparing relative expression and activity levels of glycosidases in biological systems. University of British Columbia | Publication | 2008-08-01 | |
| N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines. University of Alberta, University of British Columbia | Publication | 2008-05-01 | |
| Glycosyltransferases: structures, functions, and mechanisms. University of British Columbia | Publication | 2008-01-01 | |
| Iminoalditol-amino acid hybrids: synthesis and evaluation as glycosidase inhibitors. University of British Columbia | Publication | 2007-09-01 | |
| Recruitment of both uniform and differential binding energy in enzymatic catalysis: xylanases from families 10 and 11. University of British Columbia | Publication | 2007-06-01 | |
| Identification of the catalytic nucleophile in Family 42 beta-galactosidases by intermediate trapping and peptide mapping: YesZ from Bacillus subtilis. University of British Columbia | Publication | 2007-05-01 | |
| Gas phase noncovalent protein complexes that retain solution binding properties: Binding of xylobiose inhibitors to the beta-1, 4 exoglucanase from cellulomonas fimi. University of British Columbia | Publication | 2007-01-01 | |
| Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis. University of Alberta, University of British Columbia | Publication | 2006-12-01 | |
| Fine tuning of beta-glucosidase inhibitory activity in the 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) system. University of British Columbia | Publication | 2006-07-01 | |
| Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. University of British Columbia | Publication | 2006-06-01 | |
| An atypical approach identifies TYR234 as the key base catalyst in chondroitin AC lyase. University of British Columbia | Publication | 2006-04-01 | |
| Glycosylation of a neoglycoprotein by using glycosynthase and thioglycoligase approaches: the generation of a thioglycoprotein. University of British Columbia | Publication | 2006-04-01 | |
| Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction. University of British Columbia | Publication | 2005-06-01 | Xia Z, Azurmendi HF, Lairson LL, Stephen G. Withers, Gabelli SB, Bianchet MA, Amzel LM, Mildvan AS |
| Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate. University of British Columbia | Publication | 2005-01-01 | |
| Directed evolution of a glycosynthase from Agrobacterium sp. increases its catalytic activity dramatically and expands its substrate repertoire. University of British Columbia | Publication | 2004-10-01 | |
| Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients. University of British Columbia | Publication | 2004-04-01 | |
| Using substrate engineering
to harness enzymatic promiscuity and expand biological catalysis University of Alberta, University of British Columbia | Publication | 2006-10-01 | |
| Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes University of British Columbia | Publication | 2015-01-01 | |
| Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri LankaDO-2, DO-6 University of British Columbia | Publication | 2017-12-01 | Ryan M Centko, Pamoda B Ratnaweera, Christina Tysoe, Stephen G. Withers, E Dilip de Silva, Raymond J Andersen |
| N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases University of Manitoba, University of British Columbia | Publication | 2016-01-01 | |
| Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. University of California, Berkeley, University of British Columbia | Publication | 2002-10-01 | |
| Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor. Simon Fraser University, University of British Columbia | Publication | 2001-11-01 | |
| Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. Simon Fraser University, University of British Columbia | Publication | 2001-03-01 | |
| Identification of glu-277 as the catalytic nucleophile of Thermoanaerobacterium saccharolyticum beta-xylosidase using electrospray MS. Simon Fraser University, University of British Columbia | Publication | 1998-10-01 | |
| Biomining active cellulases from a mining bioremediation system University of British Columbia | Publication | 2013-09-01 | |
| Mutational analysis in the glycone binding pocket of Dalbergia cochinchinensis Beta-glucosidase to increase catalytic efficiency toward mannosides University of British Columbia | Publication | 2013-05-01 | Ratananikom K, Choengpanya K, Tongtubtim N, Charoenrat T, Stephen G. Withers, Kongsaeree PT |
| α-Galacturonidase(s): a new class of Family 4 glycoside hydrolases with strict specificity and a unique CHEV active site motif University of British Columbia | Publication | 2013-03-01 | |
| The 'mirror-image' postulate as a guide to the selection and evaluation of pyrrolidines as α-l-fucosidase inhibitors University of British Columbia | Publication | 2013-02-01 | |
| Investigating the structural dynamics of α-1,4-galactosyltransferase C from Neisseria meningitidis by nuclear magnetic resonance spectroscopy University of British Columbia | Publication | 2013-01-01 | |
| Purification and quantitation of bacteriophage M13 using desalting spin columns and digital PCR University of British Columbia | Publication | 2012-10-01 | |
| Directed evolution of a Beta-glycosidase from Agrobacterium sp. to enhance its glycosynthase activity toward C3-modified donor sugars University of British Columbia | Publication | 2012-09-01 | |
| Development of new and selective Trypanosoma cruzi trans-sialidase inhibitors from sulfonamide chalcones and their derivatives University of British Columbia | Publication | 2009-10-01 | |
| Structural and kinetic characterizations of the polysialic acid O-acetyltransferase OatWY from Neisseria meningitidis. University of Alberta, University of British Columbia | Publication | 2009-09-01 | |
| Designer enzymes for glycosphingolipid synthesis by directed evolution. University of British Columbia | Publication | 2009-07-01 | |
| The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design. University of Guelph, University of British Columbia, University of Alberta | Publication | 2008-11-01 | |
| A beta-1,4-galactosyltransferase from Helicobacter pylori is an efficient and versatile biocatalyst displaying a novel activity for thioglycoside synthesis. National Research Council, University of British Columbia, University of Alberta | Publication | 2008-07-01 | |
| Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of beta-glucuronides. University of British Columbia | Publication | 2008-04-01 | |
| Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols--a proof-of-concept study. University of British Columbia | Publication | 2008-03-01 | Steiner AJ, Stütz AE, Wrodnigg TM, Tarling CA, Stephen G. Withers, Hermetter A, Schmidinger H |
| Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms. University of Alberta, University of British Columbia | Publication | 2007-06-01 | |
| NMR spectroscopic characterization of a beta-(1,4)-glycosidase along its reaction pathway: stabilization upon formation of the glycosyl-enzyme intermediate. University of British Columbia | Publication | 2007-02-01 | |
| Unambiguous determination of the ionization state of a glycoside hydrolase active site lysine by 1H-15N heteronuclear correlation spectroscopy. University of British Columbia | Publication | 2006-12-01 | |
| Active-site peptide "fingerprinting" of glycosidases in complex mixtures by mass spectrometry. Discovery of a novel retaining beta-1,4-glycanase in Cellulomonas fimi. University of British Columbia | Publication | 2005-10-01 | |
| Engineering of a thioglycoligase: randomized mutagenesis of the acid-base residue leads to the identification of improved catalysts. University of British Columbia | Publication | 2005-01-01 | |
| Structural, thermodynamic, and kinetic analyses of tetrahydrooxazine-derived inhibitors bound to beta-glucosidases. University of British Columbia | Publication | 2004-11-01 | |
| Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+ -dependent phospho-alpha-glucosidase from Bacillus subtilis. University of British Columbia | Publication | 2004-09-01 | Rajan SS, Yang X, Collart F, Yip VL, Stephen G. Withers, Varrot A, Thompson J, Davies GJ, Anderson WF |
| Crystal structure of Thermotoga maritima alpha-L-fucosidase. Insights into the catalytic mechanism and the molecular basis for fucosidosis. University of British Columbia | Publication | 2004-03-01 | Sulzenbacher G, Bignon C, Nishimura T, Tarling CA, Stephen G. Withers, Henrissat B, Bourne Y |
| A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis. Ryerson University, University of British Columbia | Publication | 2013-10-01 | |
| Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs. University of Alberta, University of British Columbia | Publication | 2001-02-01 | |
| Insights into Heptosyltransferase I Catalysis and Inhibition through the Structure of Its Ternary ComplexAM-5 University of British Columbia | Publication | 2018-08-01 | |
| Probing the role of an invariant active site His in family GH 1 $\upbeta$-glycosidasesRG-2 University of British Columbia | Publication | 2019-05-10 | Andrea Strazzulli, Giuseppe Perugino, Marialuisa Mazzone, Mosè Rossi, Stephen G. Withers, Marco Moracci |
| Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides Simon Fraser University, University of British Columbia | Publication | 2011-10-01 | |
| Family 39 alpha-l-iduronidases and beta-D-xylosidases react through similar glycosyl-enzyme intermediates: identification of the human iduronidase nucleophile. University of British Columbia | Publication | 2003-07-01 | |
| Structure-based Mutagenic Analysis of Mechanism and Substrate Specificity in Mammalian Glycosyltransferases: Porcine ST3Gal-I Ryerson University, University of British Columbia | Publication | 2013-05-01 | |
| Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease University of British Columbia | Publication | 2012-03-01 | |
| Mechanistic insights into the 1,3-xylanases: useful enzymes for manipulation of algal biomass University of British Columbia | Publication | 2012-02-01 | |
| Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni University of Alberta, University of British Columbia | Publication | 2011-10-01 | |
| Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis University of Alberta, University of British Columbia | Publication | 2011-10-01 | |
| OGA inhibition by GlcNAc-selenazoline University of Alberta, University of British Columbia | Publication | 2010-10-01 | |
| Fluorescence activated cell sorting as a general ultra-high-throughput screening method for directed evolution of glycosyltransferases University of Alberta, University of British Columbia | Publication | 2010-08-01 | |
| NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base University of Alberta, University of British Columbia | Publication | 2009-12-01 | |
| 2-Acetamino-1,2-dideoxynojirimycin-lysine hybrids as hexosaminidase inhibitors. University of British Columbia | Publication | 2009-05-01 | Steiner AJ, Schitter G, Stütz AE, Wrodnigg TM, Tarling CA, Stephen G. Withers, Mahuran DJ, Tropak MB |
| 1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors. University of British Columbia | Publication | 2008-12-01 | Steiner AJ, Schitter G, Stütz AE, Wrodnigg TM, Tarling CA, Stephen G. Withers, Fantur K, Mahuran D, Paschke E, Tropak M |
| Specificity fingerprinting of retaining beta-1,4-glycanases in the Cellulomonas fimi secretome using two fluorescent mechanism-based probes. University of British Columbia | Publication | 2007-11-01 | |
| Thioglycoligase-based assembly of thiodisaccharides: screening as beta-galactosidase inhibitors. University of British Columbia | Publication | 2007-09-01 | |
| Structural and mechanistic analyses of endo-glycoceramidase II, a membrane-associated family 5 glycosidase in the Apo and GM3 ganglioside-bound forms. University of British Columbia | Publication | 2007-05-01 | |
| Quantitative continuous assay for hyaluronan synthase. University of British Columbia | Publication | 2007-02-01 | |
| D-Glucosylated derivatives of isofagomine and noeuromycin and their potential as inhibitors of b-glycoside hydrolases University of British Columbia | Publication | 2015-01-01 | |
| Structure and mechanism of chitin deacetylase from the fungal pathogen Colletotrichum lindemuthianum. University of British Columbia | Publication | 2006-08-01 | Blair DE, Hekmat O, Schüttelkopf AW, Shrestha B, Tokuyasu K, Stephen G. Withers, Van Aalten DM |
| Glycosynthase-mediated synthesis of glycosphingolipids. Seneb Biosciences, University of British Columbia | Publication | 2006-05-01 | |
| Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics. University of British Columbia | Publication | 2006-03-01 | |
| Synthesis and kinetic analysis of the N-acetylhexosaminidase inhibitor XylNAc-isofagomine. University of Alberta, University of British Columbia | Publication | 2005-09-01 | |
| Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A. University of British Columbia | Publication | 2004-08-01 | |
| Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis. University of Alberta, University of British Columbia | Publication | 2011-10-01 | |
| The Novel Glycosidase Inhibition Motif of Montbretin A, a Template For a New Class of Potential Anti-DiabeticsDO-2, DO-6 University of British Columbia | Publication | 2016-05-18 | Sami Caner, Christina Tysoe, "Mason A W ", "Williams L K ", "Zhang X ", Stephen G. Withers, Gary Brayer |
| Towards Synthesizable High Affinity Human Pancreatic Alpha-Amylase Inhibitors - A New Class of Potential Anti-DiabeticsDO-2, DO-6 University of British Columbia | Publication | 2016-07-17 | Sami Caner, Christina Tysoe, "Mason A W ", "Zhang X ", "Williams L K ", Stephen G. Withers, Gary Brayer |
| Characterization of a thermostable endoglucanase from Cellulomonas fimi ATCC484TP-1 University of British Columbia, Ryerson University | Publication | 2017-10-01 | |
| Passaging of an influenza A(H1N1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit I106M neuraminidase mutantTP-1 University of British Columbia | Publication | 2019-09-01 | Jennifer L McKimm-Breschkin, Susan Barrett, Charley McKenzie-Kludas, Julie McAuley, Victor A Streltsov, Stephen G. Withers |
| Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi. Simon Fraser University, University of British Columbia | Publication | 2006-07-01 | |
| Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy University of British Columbia | Publication | 2014-06-01 | Zoidl M, Müller B, Torvisco A, Christina Tysoe, Benazza M, Siriwardena A, Stephen G. Withers, Wrodnigg TM |
| Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights University of British Columbia | Publication | 2014-03-01 | |
| The mechanism of cellulose hydrolysis by a two-step, retaining cellobiohydrolase elucidated by structural and transition path sampling studies University of British Columbia | Publication | 2014-01-01 | Knott BC, Haddad Momeni M, Crowley MF, Mackenzie LF, Götz AW, Sandgren M, Stephen G. Withers, Ståhlberg J, Beckham GT |
| A fluorescent probe for GM1 gangliosidosis related beta-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol University of British Columbia | Publication | 2011-11-01 | Fröhlich RF, Fantur K, Furneaux RH, Paschke E, Stütz AE, Wicki J, Stephen G. Withers, Wrodnigg TM |
| Fluorous iminoalditols: a new family of glycosidase inhibitors and pharmacological chaperones University of British Columbia | Publication | 2010-09-01 | Schitter G, Steiner AJ, Pototschnig G, Scheucher E, Thonhofer M, Tarling CA, Stephen G. Withers, Fantur K, Paschke E, Mahuran DJ, Rigat BA, Tropak MB, Illaszewicz C, Saf R, Stütz AE, Wrodnigg TM |
| Synthesis and biological evaluation of novel biotin-iminoalditol conjugates University of British Columbia | Publication | 2010-07-01 | Pototschnig G, De Csáky CM, Burke JR, Schitter G, Stütz AE, Tarling CA, Stephen G. Withers, Wrodnigg TM |
| Imaging of enzyme replacement therapy using PETRG-2 University of British Columbia | Publication | 2010-06-01 | |
| Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors University of British Columbia | Publication | 2010-01-01 | Schitter G, Scheucher E, Steiner AJ, Stütz AE, Thonhofer M, Tarling CA, Stephen G. Withers, Wicki J, Fantur K, Paschke E, Mahuran DJ, Rigat BA, Tropak M, Wrodnigg TM |
| Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. University of British Columbia | Publication | 2008-07-01 | Lee YS, Lee MH, Lee HS, Lee SJ, Kim YW, Zhang R, Stephen G. Withers, Kim KS, Lee SJ, Park KH |
| The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates. University of British Columbia | Publication | 2008-04-01 | Newstead SL, Potter JA, Wilson JC, Xu G, Chien CH, Watts AG, Stephen G. Withers, Taylor GL |
| Probing electrostatic interactions along the reaction pathway of a glycoside hydrolase: histidine characterization by NMR spectroscopy. University of British Columbia | Publication | 2007-06-01 | Schubert M, Poon DK, Wicki J, Tarling CA, Kwan EM, Nielsen JE, Stephen G. Withers, McIntosh LP |
| Glycosynthase-based synthesis of xylo-oligosaccharides using an engineered retaining xylanase from Cellulomonas fimi. University of British Columbia | Publication | 2006-05-01 | |
| Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols. University of British Columbia | Publication | 2006-04-01 | Greimel P, Häusler H, Lundt I, Rupitz K, Stütz AE, Tarling CA, Stephen G. Withers, Wrodnigg TM |
| Cloning and characterization of Thermotoga maritima beta-glucuronidase. University of British Columbia | Publication | 2006-01-01 | |
| Evaluation of a new system for developing particulate enzymes based on the surface (S)-layer protein (RsaA) of Caulobacter crescentus: fusion with the beta-1,4-glycanase (Cex) from the cellulolytic bacterium Cellulomonas fimi yields a robust, catalyt University of British Columbia | Publication | 2005-11-01 | Duncan G, Tarling CA, Bingle WH, Nomellini JF, Yamage M, Dorocicz IR, Stephen G. Withers, Smit J |
| Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue. University of Alberta, University of British Columbia | Publication | 2004-07-01 | |
| Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog. University of Alberta, University of British Columbia | Publication | 2004-02-01 | |
| Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog University of Alberta, University of British Columbia | Publication | 2004-02-01 | |
| A plate-based high-throughput activity assay for polysialytransferase from Neisseria meningitidis University of British Columbia | Publication | 2014-01-01 | Ching-Ching Yu, Tara Hill, David H. Kwan, Hongming Chen, Chun-Cheng Lin, Warren Wakarchuck, Stephen G. Withers |
| Structural and mechanistic analysis of a beta-glycoside phosphorylase identified by screening a metagenomic libraryTP-1 University of Manitoba, University of British Columbia | Publication | 2018-01-01 | |
| Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds α-maltose 1-phosphate and forms a maltosyl-enzyme intermediate University of British Columbia | Publication | 2014-04-01 | Syson K, Stevenson CE, Rashid AM, Saalbach G, Tang M, Tuukkanen A, Svergun DI, Stephen G. Withers, Lawson DM, Bornemann S |
| Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase University of British Columbia | Publication | 2013-05-01 | |
| 1-Deoxy-D-galactonojirimycins with dansyl capped N-substituents as beta-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines University of British Columbia | Publication | 2011-09-01 | Fröhlich RF, Furneaux RH, Mahuran DJ, Saf R, Stütz AE, Tropak MB, Wicki J, Stephen G. Withers, Wrodnigg TM |
| Self-immobilizing fluorogenic imaging agents of enzyme activity University of British Columbia | Publication | 2011-01-01 | Kwan DH, Chen HM, Ratananikom K, Hancock SM, Watanabe Y, Kongsaeree PT, Samuels AL, Stephen G. Withers |
| 1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines University of British Columbia | Publication | 2010-07-01 | Fröhlich RF, Furneaux RH, Mahuran DJ, Rigat BA, Stütz AE, Tropak MB, Wicki J, Stephen G. Withers, Wrodnigg TM |
| Chitinase inhibition by chitobiose and chitotriose thiazolines University of British Columbia | Publication | 2010-03-01 | Macdonald JM, Tarling CA, Taylor EJ, Dennis RJ, Myers DS, Spencer Knapp, Davies GJ, Stephen G. Withers |
| Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis. University of British Columbia | Publication | 2008-03-01 | Damager I, Buchini S, Amaya MF, Buschiazzo A, Alzari P, Frasch AC, Watts A, Stephen G. Withers |
| The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system. University of British Columbia | Publication | 2007-01-01 | |
| Thermostable glycosynthases and thioglycoligases derived from Thermotoga maritima beta-glucuronidase. University of British Columbia | Publication | 2006-07-01 | |
| NAD+ and metal-ion dependent hydrolysis by family 4 glycosidases: structural insight into specificity for phospho-beta-D-glucosides. University of British Columbia | Publication | 2005-02-01 | Varrot A, Yip VL, "Yunsong Li ", Rajan SS, Yang X, Anderson WF, Thompson J, Stephen G. Withers, Davies GJ |
| An unusual mechanism of glycoside hydrolysis involving redox and elimination steps by a family 4 beta-glycosidase from Thermotoga maritima. University of British Columbia | Publication | 2004-07-01 | Yip VL, Varrot A, Davies GJ, Rajan SS, Yang X, Thompson J, Anderson WF, Stephen G. Withers |
| Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase. University of British Columbia | Publication | 2013-05-01 | |
| Structural and biochemical characterization of glycoside hydrolase family 79 beta-glucuronidase from Acidobacterium capsulatum. University of British Columbia | Publication | 2012-04-01 | Michikawa M, Ichinose H, Momma M, Biely P, Jongkees S, Yoshida M, Kotake T, Tsumuraya Y, Stephen G. Withers, Fujimoto Z, Kaneko S |
| Towards efficient enzymes for the generation of universal blood through structure-guided directed evolution University of Victoria, University of British Columbia | Publication | 2015-01-01 | |
| Potent GH 20 N-Acetyl-beta-D-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediolsRG-2 University of British Columbia | Publication | 2018-03-20 | Patrick Weber, Seyed Nasseri, Bettina Pabst, Ana Torvisco, Philipp Müller, Eduard Paschke, Marion Tschernutter, Werner Windischhofer, Stephen G. Withers, Tanja Wrodnigg, Arnold Stütz |
| Discovery of UDP -Glycosyltransferases and BAHD-Acyltransferases in the Biosynthesis of the Anti-Diabetic Plant Metabolite Montbretin ADO-2 University of British Columbia | Publication | 2018-07-01 | Sandra Irmisch, JennySeoHyun Jo, Christopher Roach, Sharon Jancsik, Macaire M S Yuen, Lina Madilao, Mark Mark O\textquotesingle Neil-Johnson, Russell Williams, Stephen G. Withers, Joerg Bohlmann |
| Circular permutation of Bacillus circulans xylanase: a kinetic and structural study University of British Columbia | Publication | 2010-03-01 | Reitinger S, Yu Y, Wicki J, Ludwiczek M, D'Angelo I, Baturin S, Okon M, Natalie Strynadka, Lutz S, Stephen G. Withers, McIntosh LP |
| Structural insight into mammalian sialyltransferases University of Alberta, Seneb Biosciences, University of British Columbia | Publication | 2009-11-01 | Rao FV, Rich JR, Rakić B, Buddai S, Schwartz MF, Johnson K, Bowe C, Warren W. Wakarchuk, Shawn Defrees, Stephen G. Withers, Natalie Strynadka |
| Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors. University of British Columbia | Publication | 2004-07-01 | Wrodnigg TM, Diness F, Gruber C, Häusler H, Lundt I, Rupitz K, Steiner AJ, Stütz AE, Tarling CA, Stephen G. Withers, Wölfler H |
| Circular permutation of Bacillus circulans xylanase: a kinetic and structural study. University of British Columbia | Publication | 2010-03-01 | Reitinger S, Yu Y, Wicki J, Ludwiczek M, D'Angelo I, Baturin S, Okon M, Natalie Strynadka, Lutz S, Stephen G. Withers, McIntosh LP |
| Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase. Simon Fraser University, University of British Columbia | Publication | 2004-01-01 | Yang JK, Yoon HJ, Ahn HJ, Lee BI, Pedelacq JD, Liong EC, Berendzen J, Laivenieks M, Vieille C, Zeikus GJ, David Vocadlo, Stephen G. Withers, Suh SW |
| The amylase inhibitor montbretin A reveals a new glycosidase inhibition motifDO-2, DO-6 University of British Columbia | Publication | 2015-07-01 | Leslie K Williams, Xiaohua Zhang, Sami Caner, Christina Tysoe, Nham T Nguyen, Jacqueline Wicki, David E Williams, John Coleman, John H McNeill, Violet Yuen, Raymond J Andersen, Stephen G. Withers, Gary Brayer |
| Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity Zucara Therapeutics, University of British Columbia | Publication | 2013-04-01 | Kim JH, Resende R, Wennekes T, Chen HM, Bance N, Buchini S, Watts AG, Pilling P, Streltsov VA, Petric M, Richard Liggins, Barrett S, McKimm-Breschkin JL, Niikura M, Stephen G. Withers |
Help/FAQ
