ProfileYvan Guindon is a Research Professor at the Institut de recherches cliniques de Montréal (IRCM) and at the Department of Chemistry, Université de Montréal. He obtained his B.Sc. and Ph.D at the Université de Montréal. He started at Merck Frosst in 1979 and held different leading positions including Senior Director of Medicinal Chemistry. From 1987 to 2004, he was Vice-President Research at BioMega/Boehringer Ingelheim Research Canada. He moved to Academic in 1994 when he directed the Bio-Organic Chemistry Laboratory, From 1994 to 2004, he was also Chief Executive Officer and Scientific Director of the IRCM. His research interests were centered on the discovery of potential therapeutics for asthma, hypertension, HIV and other viral infections. Recently, his work targets anti-inflammatory pathways and pancreatic cancer in collaboration with Dr. Nemer’s Laboratory (University of Ottawa). His group is aiming to discover cardio-protective agents for patients receiving antineoplastic drugs. He is also recognized for his contribution in free-radical chemistry and the synthesis of natural products and nucleoside analogues. Dr. Guindon was elected to the Academy of Sciences of the Royal Society of Canada in 1990. He was named to the Order of Canada in 2005. In 2006, he received the Prix Lionel-Boulet, Prix du Québec, for his contributions to the biopharmaceutical sector. He was President from 2007-2009 of the RSC: The Academies of Arts, Humanities and Sciences of Canada (The Royal Society of Canada). In 2012, he received the Alfred-Bader Award, from the Canadian Society for Chemistry, for the excellence of his contributions in Organic Chemistry. He was also received as a Knight of National Order of Québec the same year. He is Fellow of the American Association for the Advancement of Science since 2014. GlycoNet Funded ProjectsProducts
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| Synthesis of Sialyl LewisX Glycomimetics Bearing a Bicyclic 3-O, 4-C-Fused Galactopyranoside ScaffoldCD-3 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2019-05-01 | Ryan Simard, Mathieu Joyal, Laura Gillard, Gianna Di Censo, Wael Maharsy, Janie Beauregard, Pina Colarusso, Kamala D Patel, Michel Prévost, Mona Nemer, Yvan Guindon | | Investigation of Diastereoselective Acyclic a-Alkoxydithioacetal Substitutions Involving Thiacarbenium Intermediates - DOI: 10.1021/jo502181A (asap) University of Montreal | Publication | 2014-10-01 | | | Synthesis of 1',2'-cis-Nucleoside Analogues : Evidence of Stereoelectronic Control for SN2 Reactions at the Anomeric Center of Furanosides University of Montreal | Publication | 2010-09-01 | | | Synthesis of 2,3-anti-3,4-anti and 2,3-anti-3,4syn Propionate Motifs: A Diastereoselective Tandem Sequence of Mukaiyama and Free-Radical Based Hydrogen Transfer Reactions University of Montreal | Publication | 2002-03-01 | | | SIALYL LEWIS X ANALOGUES AS SELECTIN ANTAGONISTS FOR THE TREATMENT OF VASCULAR OCCLUSIONS AND INFLAMMATORY DISEASECD-3 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-05-19 | | | Sialyl Lewis X Analogues As Selectin Antagonists for the Treatment of Vascular Occlusions and Inflammatory DiseaseCD-3 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-05-13 | | | Sialyl Lewis X Analogues As Selectin Antagonists for the Treatment of Vascular Occlusions and Inflammatory DiseaseCD-3 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-08-26 | | | Sialyl Lewis X Analogues As Selectin Antagonists for the Treatment of Vascular Occlusions and Inflammatory DiseaseCD-3 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-08-26 | | | Diastereoselective Hydrogen Transfer Reactions : An Experimiental and DFT study University of Montreal | Publication | 2013-06-01 | François Godin, Michel Prévost, Gorelsky S I, Mochirian P*, Nguyen M*, Viens F*, Yvan Guindon | | A Study of Exocyclic Radical Reductions of Polysubstituted Tetrahydropyrans University of Montreal | Publication | 2013-05-01 | François Godin, Michel Prévost, Viens F*, Mochirian P*, Brazeau J F*, Gorelsky S I, Yvan Guindon | | A Study of the Endocyclic versus Exocyclic C–O Bond Cleavage Pathways of alpha- and beta-Methyl Furanosides | Publication | 2013-03-01 | St-Jean O*, Michel Prévost, Guindon, Y | | A Stereoselective Approach to b-L-Arabino Nucleoside Analogues: Synthesis and Cyclization of Acyclic 1',2'-syn N,O-acetals University of Montreal | Publication | 2012-09-01 | | | Synthesis of Propionate Motifs: Diastereoselective Tandem Reactions Involving Anionic and Free Radical-Based Processes University of Montreal | Publication | 2001-09-01 | Houde K*, Michel Prévost, Cardinal-David B*, Landry S R*, Daoust B*, Bencheqroun M*, Guérin B*, Yvan Guindon | | Diastereoselective Synthesis of C2′-Fluorinated Nucleoside Analogues Using an Acyclic Approach CD-15 Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2016-10-13 | | | Functionalized Nucleotides as Biomarkers for Polθ ActivityCD-44 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-05-13 | Starr Dostie, Michel Prévost, Amarender Manchoju, Renaud Zelli, Carla Eymard, Yvan Guindon | | Selected Diastereoselective Reaction - Free Radical Additions and Cyclizations University of Montreal | Publication | 2012-07-01 | | | A Stereoselective Approach to Nucleosides and 4'-thioanalogues from Acyclic Precursors University of Montreal | Publication | 2009-12-01 | Chapdelaine D*, Cardinal-David B*, Michel Prévost, Gagnon M*, Thumin I*, Yvan Guindon | | Stereopentads Derived from a Sequence of Mukaiyama Aldolization and Free Radical Reduction on a-Methyl-B-Alkoxy Aldehydes: A General Strategy for Efficient Polypropionate Synthesis University of Montreal | Publication | 2009-01-01 | | | Diastereoselective Synthesis of Nucleoside Analogues via Cyclization of Acyclic Precursors CD-31, CD-66 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-06-07 | | | From Free Radical Chemistry To Novel Classes Of Bioactive MoleculesCD-31, CD-43, CD-66 Institut de recherches cliniques de Montréal, University of Montreal, University of Ottawa | Presentation | 2019-08-27 | | | Diastereoselective and Regioselective Synthesis of Adenosine Thionucleoside Analogues Using an Acyclic ApproachCD-31 Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2020-03-12 | "Benoit Cardinal-David ", "Marc-Olivier Labbe ", Michel Prévost, Starr Dostie, Yvan Guindon | | Dual-Face Nucleoside Scaffold Featuring a Stereogenic All-Carbon Quaternary Center. Intramolecular Silicon Tethered Group-transfer Reactions University of Montreal | Publication | 2014-11-01 | Tambutet G*, Becerril-Jiménez F*, Starr Dostie, Michel Prévost, Mochirian P*, Yvan Guindon | | Synthesis of Polypropionate Motifs Contaning the Anti-Anti Units University of Montreal | Publication | 2002-09-01 | Mochirian P*, Cardinal-David B*, Guérin B*, Michel Prévost, Yvan Guindon | | A New Generation of Sialyl LewisX Glycomimetics Bearing a Bicyclic 3-O, 4-C-Fused Galactopyranoside ScaffoldCD-3 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-06-07 | | | A New Generation of Sialyl LewisX Glycomimetics Bearing a Bicyclic 3-O, 4-C-Fused Galactopyranoside ScaffoldCD-3 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-11-10 | | | Synthesis of a novel class of nucleosides bearing an all-carbon quaternary centerCD-31, CD-44 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-11-09 | Renaud Zelli, Tommy Lussier, Amarender Manchoju, Starr Dostie, Michel Prévost, Yvan Guindon | | Synthesis of nucleoside analogues using acyclic diastereoselective reactionsCD-31 Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2019-04-29 | Tommy Lussier, "Marie-Eve Waltz ", Garrett Freure, "Philippe Mochirian ", Starr Dostie, Michel Prévost, Yvan Guindon | | Acyclic Tethers Mimicking Subunits of Polysaccharide Ligands : Selectin Antagonists University of Montreal | Publication | 2014-07-01 | Calosso M*, Tambutet G*, Charpentier D*, Vaillancourt M*, Bencheqroun M*, Gratton JF, Michel Prévost, Yvan Guindon | | Diastereoselective Synthesis of Arabino- and Ribo-like Nucleoside Analogues Bearing a Stereogenic C3’ All-Carbon Quaternary CenterCD-31, CD-44 Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2019-11-15 | Tommy Lussier, Amarender Manchoju, Gang Wang, Starr Dostie, "Scott Foster ", "Philippe Mochirian ", Michel Prévost, Yvan Guindon | | Identification of a C3’-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth. CD-31 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2020-01-21 | "Marc-Olivier Labbe ", Laura Collins, "Carole-Anne Lefebvre ", Wael Maharsy, Janie Beauregard, Starr Dostie, Michel Prévost, Mona Nemer, Yvan Guindon | | THE DEVELOPMENT OF NOVEL NUCLEOSIDE ANALOGUES CD-66 University of Ottawa, Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2020-01-24 | Carla Eymard, Amarender Manchoju, Laura Collins, Georges Kanaan, Wael Maharsy, Mona Nemer, Starr Dostie, Michel Prévost, Yvan Guindon | | Diastereoselective Synthesis of Nucleoside Analogues via Cyclization of Acyclic Precursors CD-15 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2016-06-02 | | | Identification of a C2'-Fluorinated SAH Analogue Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2020-02-16 | "Marc-Olivier Labbe ", "Fengling Li ", "Irene Chau ", "Zi-Jian Xiong ", Starr Dostie, Yvan Guindon | | Synthesis of nucleoside analogues with C2’ quaternary center CD-66 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2020-02-18 | | | Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction : Synthesis of the C17-C22 Subunit of Ionomycin University of Montreal | Publication | 1994-03-01 | Yvan Guindon, Yoakim C, Gorys V, Delorme D, Renaud Jacquemart, Robinson G, Lavallée J F, Slassi A, Jung G, Rancourt J, Liotta D, Durkin K | | Inhibition of Herpes Simplex Virus Type 1 Ribonucleotide reductase by Substituted Tetrapeptide Derivatives University of Montreal | Publication | 1993-10-01 | Yvan Guindon, Moss N, Déziel R, Adams J, Aubry N, Baillet M, Beaulieu P, DiMalo J, Duceppe J S, Ferland J M, Gauthier J, Ghiro E, Goulet S, Grenier L, Lavallée P, Lépine-Frenette C et al | | Structure of Dimethyl (2R,3R)-2-{[(S)-Bromo(cyclohexyl)methyl]oxy}-3-[(Diphenyl-boryl)oxy]-1,4-butanedioate University of Montreal | Publication | 1993-01-01 | | | Stereoselective Silver Triflate-Mediated Iodocyclization of Carbamates University of Montreal | Publication | 1992-07-01 | | | Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals : A Study of Radical Conformations Using Semi-Empirical Calculations University of Montreal | Publication | 1992-06-01 | Yvan Guindon, Durkin K, Liotta D, Rancourt J, Lavallée J F, Boisvert L | | Stereoselective Chelation-Controlled Reductions of A-iodo-B-Alkoxy Esters Under Radical Conditions University of Montreal | Publication | 1991-12-01 | Yvan Guindon, Lavallée J F, Linas-Brunet M, Horner G, Rancourt J | | Discovery and Development of Two Potent Therapeutic Agents in the Indole Series : MK-886, A New Biosynthesis Inihibior of Leukotriene and L-670,596, A New Thromboxane Receptor Antagonist University of Montreal | Publication | 1991-12-01 | Yvan Guindon, Girard Y, Dixon R, Ethier D, Evans J, Ford-Hutchinson A, Fortin R, Hamel P, Jones T et al | | Stereoselective Opening of Acetals Derived from Dimethyl Tartrate University of Montreal | Publication | 1991-09-01 | Yvan Guindon, Simoneau B, Yoakim C, Gorys V, Lemieux R, Ogilvie W W | | Indole-2-Alkanoic Acids: A New Class of Biologically Active Molecules. Thromboxane Antagonists University of Montreal | Publication | 1991-02-01 | Yvan Guindon, Gillard J W, Fortin R, Yoakim C, Morton H, Hall R A, Letts G, Jones T R, Masson P, Maycock A, Ford-Hutchinson A.W, Ethier D, Lord A, Yusko P, Rokach J | | Specific Inhibition of Ribonucleotide Reductases by Peptides Corresponding to the C-Terminal of their Second Subunit University of Montreal | Publication | 1991-01-01 | Yvan Guindon, Cosentino G, Lavallée P, Rakhit S, Plante R, Gaudette Y, Lawetz C, Whitehead P W, Duceppe J S, Lépine-Frenette C, Dansereau N, Guilbault C, Gaudreau P, Langelier Y, Thelander L | | Stereoselective Radical-Mediated Reduction and Alkylation of a-halo Esters University of Montreal, Université de Sherbrooke | Publication | 1991-01-01 | | | Dialkyl and Diaryl Boron Halides : Reductive Opening of Benzylidene Acetals University of Montreal | Publication | 1990-06-01 | Yvan Guindon, Girard Y, Berthiaume S, Gorys V, Lemieux R, Yoakim C | | Stereoselective Reduction of Acyclic a-Bromo Esters University of Montreal | Publication | 1990-05-01 | Yvan Guindon, Yoakim C, Lemieux R, Boisvert L, Delorme D, Lavallée J F | | Photoaffinity Labeling of the Human Platelet Thromboxane A2/Protaglandin H2 Receptor University of Montreal | Publication | 1989-07-01 | Yvan Guindon, Mais D E, Yoakim C, Gillard J M, Rokach J, Halushka P V | | Synthesis and Structure-Activity Relationships of a Novel Class of 5- Lipoxygenase Inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5 diakylbenzoburans : The Development of L-656,224 University of Montreal | Publication | 1989-06-01 | Yvan Guindon, Lau C K, Bélanger P C, Scheigetz J, Dufresne C, Williams H W R, Maycock A L, Bach T, Dallob A L, Denis D, Ford-Hutchinson A W, Gale P H, Hopple S L, Letts L G, Luell S, Macfarlane C S et al | | Diastereoselective Synthesis of 2,3-Disubstituted Tetrahydrofuran Synthons via the Iodoetherification Reaction. A Transition State Model Based Rationalization of the Allylic Asymmetric Induction University of Montreal | Publication | 1989-03-01 | | | Tetrahydrocarbazol-1-Acetic Acids : New Class of Thromboxane Receptor Antagonists University of Montreal | Publication | 1989-02-01 | Yvan Guindon, Girard Y, Yoakim-Rancourt C, Hamel P, Gillard J W, Letts G, Evans J, Leveille C, Ethier D et al. | | New Synthetic Applications of Dialkylboron Halide Reagents University of Montreal | Publication | 1988-11-01 | Yvan Guindon, Anderson P C, Yoakim C, Girard Y, Berthiaume S, Morton H E | | Homoallylic Chiral Induction in the Synthesis of 2,4-Disubstituted Tetrahydrofurans by iodoetherification. Synthetic Scope and Chiral Induction Mechanism University of Montreal | Publication | 1988-07-01 | | | Symmetrical Alkoxysilyl Ethers. A New Class of Alcohol-Protecting Groups. Preparation of tert-Butoxydiphenylsilyl Ethers University of Montreal | Publication | 1988-05-01 | Yvan Guindon, Gillard J W, Fortin R, Morton H E, Yoakim C, Quesnelle C A, Daigneault S | | L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3-methyl-5-propyl-4-benzofuranol): A novel, Selective Orrally Active-5-lipoxygenase inhibitor University of Montreal | Publication | 1987-12-01 | Yvan Guindon, Bélanger P, Maycock A, Bach T, Dollob A L, Dufresne C, Ford-Hutchinson A W, Gale P H, Hopple S, Lau C K, Letts L G, Luell S, MacFarlane C S, Macintyre E, Meurer R, Miller D K et al. | | The Leukotrienes: Prospects for Therapy Against a Unique Family of Pathophysiological Mediators University of Montreal | Publication | 1987-12-01 | | | Exceptionally Mild and Stereospecific Ring Fragmentations Promoted by Dimethylboron Bromide University of Montreal | Publication | 1987-11-01 | | | Total Synthesis of Leukotriene B4 Analogues. 3-Thia-LTB4 and 3-Thia-20-tribluoro-LTB4 University of Montreal | Publication | 1987-06-01 | | | Stereoeelectronic Effects in the Ring Cleavage of Methyl Glycopyranosides Using Dimethylboron Bromide University of Montreal | Publication | 1987-05-01 | | | Ring Cleavage of THP et THF Ethers Using Dimethylboron Bromide University of Montreal | Publication | 1987-05-01 | | | Regiocontrolled Opening of Cyclic Ethers Using Dimethylboron Bromide University of Montreal | Publication | 1987-05-01 | | | Pharmacology of L-655,240 (3-[1-4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-Dimethylpropanoic Acid); A. Potent, Selective Thromboxane/Prostaglandin University of Montreal | Publication | 1987-03-01 | Yvan Guindon, Hall R A, Gillard J, Letts G, Champion E, Ethier D, Evans J, Ford-Hutchinson A W, Fortin R, Jones T R, Lord A, Morton H, Rokach J, Yoakim C | | L-648,051 : An Aerosol Active Leukotriene D4 Receptor Antagonist University of Montreal | Publication | 1987-02-01 | Yvan Guindon, Jones T R, Champion E, Charette L, DeHaven R N, Denis D, Ethier D, Ford-Hutchinson A W, Fortin R, Frenette R, Gauthier J Y, Hamel R, Masson P, Maycock A, McFarlane C et al. | | Novel Arylthio-and Arylsulfonylpropyloxyacetophenones: Design and Synthesis of L-648-051 and L-649,923, Potent Antagonists of Leukotriene D4 University of Montreal | Publication | 1987-02-01 | Yvan Guindon, Young R N, Jones T R, Atkinson J G, Bélanger P, Champion E, Denis D, DeHaven R N, Ford-Hutchinson A W, Fortin R, Frenette R, Gauthier J Y, Gillard J, Kakushima M, Masson P, Maycock A et al. | | L-651,392 : A Novel, Potent and Selectice 5-Lipoxygenase Inhibitor University of Montreal | Publication | 1987-02-01 | Yvan Guindon, Girard Y, Maycock A, Ford-Hutchinson A W, Atkinson J G, Bélanger P C, Dallob A, DeSousa D, Dougherty H, Egan R, Goldenberg M, Ham E, Fortin R, Hamel P et al. | | Design and Synthesis of Sodium (BR*, gS*)-4-[(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-g-hydroxy-B-methylbenzenebutanoate: A Novel, Selective and Orally Active Receptor Antagonist of Leukotriene D4 University of Montreal | Publication | 1986-09-01 | Yvan Guindon, Young R N, Bélanger P, Champion E, DeHaven R N, Denis D, Ford-Hutchinson A W, Fortin R, Frenette R, Gauthier J Y, Gillard J, Jones T R, Kakushima M et al. | | L-648,051, Sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylsulfonyl)-g-oxo-benzenebutanoate: A Leukotriene D4 Receptor Antagonist University of Montreal | Publication | 1986-05-01 | Yvan Guindon, Jones T R, Young R N, Champion E, Charette L, Denis D, Étier D, Hamel R, Ford-Hutchinson A W, Fortin R, Letts G, Masson P, McFarlane C, Piechuta H et al. | | Synthetic Utility of Chiral Tetrahydrofurans: Preparation of (1R,3R,5S)-1-3-Dimethyl-2,9-Dioxabicyclo[3.3.1]Nonane University of Montreal | Publication | 1986-03-01 | | | A General Method for Determining the Anomeric Configuration of C-Furanoside Derivatives : A1H Nuclear Magnetic Resonance Nuclear Overhauser Effect Study University of Montreal | Publication | 1986-02-01 | | | L-649,923, Sodium, (BS*,gR*)-4(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylthio)--g-hydroxy-B-methylbenzenebutonoate. A Selective, Orally Active Leukotriene D4 Receptor Antagonist University of Montreal | Publication | 1986-01-01 | Yvan Guindon, Young R N, Jones T R, Ford-Hutchinson A W, Bélanger P, Champion E, Charette L, DeHaven R N, Denis D, Fortin R, Frenette R, Gauthier J Y, Gillard J W, Kakushima M, Letts L G, Masson A et al. | | L-649,923, Sodium (BS*,gR*)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxyl)propylthio)-g-hydroxy-B-methylbenzenebutanoate, A Selective, Orally Active Leukotriene Receptor Antagonist University of Montreal, Simon Fraser University | Publication | 1986-01-01 | Yvan Guindon, Jones T R, Robert Young, Champion E, Charette L, Denis D, Ford-Hutchinson A W, Frenette R, Gauthier J Y, Kakushima M, Masson P, McFarlane C, Rokach J, Zamboni R, DeHaven R N, Maycock A et al. | | Preparation of Ethyl 5(S),6-Epoxy-3(R)-(Methoxymethoxy)Hexanoate: A Key Chiral Intermediate for Mevinolin and Compactin University of Montreal | Publication | 1985-03-01 | | | Tert-Butylmethoxyphenylsilyl Ether - A New Selective, Stable Alcohol Protecting Group with Remarkable Lability to Fluoride University of Montreal | Publication | 1984-10-01 | | | Deoxygenation of Sulfoxides with Boron Bromide Reagents University of Montreal | Publication | 1984-04-01 | | | Dimethylboron Bromide and Diphenylboron Bromide: Cleavage of Acetals and Ketals University of Montreal | Publication | 1984-02-01 | | | Dimethylboron Bromide and Diphenylboron Bromide. Acetal and Ketal Cleavage. Cleavage of MEM, MOM & MTM Ethers University of Montreal | Publication | 1983-09-01 | | | Cleavage of Carbon-Oxygen Bonds. Dimethylboron Bromide. A New Reagent for Ether Cleavage University of Montreal | Publication | 1983-08-01 | | | Direct Synthesis of Thioethers from Thiols and Alcohols University of Montreal | Publication | 1983-04-01 | | | Stereospecific Synthesis of Leukotriene B4 (LTB4) University of Montreal | Publication | 1982-02-01 | | | Synthesis of B-Trimethylsilyloxythioethers and B-Hydroxythioethers by the Reaction of Epoxides with Aryl-and Alkylthiotrimethylsilanes University of Montreal | Publication | 1981-05-01 | | | Diastereoselective Radical Hydrogen Transfer Reactions using N‑Heterocyclic Carbene Boranes Institut de recherches cliniques de Montréal, University of Montreal | Publication | 2016-10-06 | | | Nucleoside and nucleotide analogues bearing a quaternary all-carbon stereogenic center at the 2’ position and methods of useUS provisional applicationCD-15 Institut de recherches cliniques de Montréal, University of Montreal, University of Ottawa | Artifact | 2017-03-22 | | | Free Radicals from Bad to Good : Novel lead molecules targeting Pancreatic Cancer. CD-3, CD-31, CD-43, CD-66 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-05-19 | | | New Class of Nucleoside Analogues Targeting Gastrointestinal TumorCD-31 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-05-14 | | | From Free Radical Chemistry to Novel Classes of Bioactive MoleculesCD-31, CD-66 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-06-06 | | | Development of Cardioprotective AgentsCD-43, CD-66 Institut de recherches cliniques de Montréal, University of Montreal | Presentation | 2019-05-14 | | | Diastereoselective Mukaiyama and Free Radical Processes for the Synthesis of Polypropionate Units University of Montreal | Publication | 2004-07-01 | | | The Use of Lewis-Acids in Radical Chemistry. Chelation-Controlled Radical Reductions of Substituted A-Bromo-B-Alkoxy Esters and Chelation-Controlled Radical Addition Reactions University of Montreal | Publication | 1998-09-01 | | | Intramolecular Oxygen Radical Additions to A-B-Unsaturated Esters. Diastereoselective Tandem Cyclofunctionalization and Hydrogen Transfer Reactions University of Montreal | Publication | 1998-01-01 | | | Pharmacological Evidence for a Role of Lipoxygenase Products in Platelet-Activating Factor (PAF)-Induced Hyperalgesia University of Montreal | Publication | 1987-02-01 | | | Dimethylboron Bromide Interconversion of Protecting Groups: Preparation of MTM Ethers, O,S-Acetals, and Cyanomethyl Ethers University of Montreal | Publication | 1985-12-01 | | | Total Synthesis of 11-Oxaprostaglandin F2A and F2B. University of Montreal | Publication | 1985-09-01 | | | Chemistry of the Glycosidic Linkage. Direct Conversion into 1-Thioglycosides by Use of [Alkyl(orAryl)Thio]Trimethylsilanes University of Montreal | Publication | 1980-09-01 | | | Cleavage of Methyl and Benzyl Ethers with Thiotrimethylsilanes University of Montreal | Publication | 1980-01-01 | | | Total Synthesis of zincophorin methyl ester. Stereocontrol of 1,2-induction using sterically hindered enoxysilanes University of Montreal | Publication | 2014-11-01 | | | Synthesis of Tertiary and Quaternary Stereogenic Centers: A Diastereoselective Tandem Reaction Sequence Combining Mukaiyama and Free Radical-Based Allylation University of Montreal | Publication | 2005-02-01 | | | Synthesis of Postulated Molecular Probes: Stereoselective Free-Radical-mediated C-Glycosylation in Tandem with Hydrogen Transfer University of Montreal | Publication | 2005-01-01 | | | Influence of N-substituted Lactams on Acyclic Free Radical Based Hydrogen Transfer University of Montreal | Publication | 2001-08-01 | | | Intramolecular Aminyl and Iminyl Radical Additions to A-B-unsaturated esters. Diastereoselective Tandem Cyclofunctionalization and Hydrogen Transfer Reactions University of Montreal | Publication | 2001-07-01 | | | Hydrogen and Allylation Transfer Reactions in Acyclic Free Radicals University of Montreal | Publication | 1998-03-01 | | | The Exo-cyclic Effect : Strategy Employing In Situ Derivatization or Lewis Acid Complexation to Enhance Stereoselectivity in Hydrogen Transfer Reactions University of Montreal | Publication | 1997-10-01 | | | Synthesis of Lipoxygenase Products University of Montreal | Publication | 1984-03-01 | | | The Preparation of Octahydro Leukotrienes C, D, and E via a Stereoselective Sulfenyllactonization Reaction University of Montreal | Publication | 1981-08-01 | Young R N, Coombs W, Yvan Guindon, Rokach J, Ethier D, Hall R | | The Stereospecific Synthesis of Leukotriene A4 (LTA4), 5-epi-LTA4, 6-epi LTA4 and 5-epi, 6-epi LTA4 University of Montreal | Publication | 1981-03-01 | Young R N, Coombs W, Yvan Guindon, Rokach J, Ethier D, Hall R | | The Synthesis of Leukotrienes University of Montreal | Publication | 1981-02-01 | Rokach J, Girard Y, Yvan Guindon, Atkinson J C, Larue M, Young R N, Masson P, Holme G | | The Synthesis of a Leukotriene with SRS-Like Activity University of Montreal | Publication | 1980-02-01 | Rokach J, Girard Y, Yvan Guindon, Atkinson J G, Larue M, Young R N, Masson P, Holme G | | Assembly of the Carbon Skeletal Framework of Erythronolike A University of Montreal | Publication | 1978-03-01 | | | Utilization of Functionalized Polymers in Synthesis : Immobilization of Carbonhydrates as Acetals, and Some Chemical Transformations University of Montreal, University of Quebec at Montreal | Publication | 1974-10-01 | | | Facile Access to Ethyl 2-C-b-D-Ribofuranosyl Acetates. (A Contribution in the Series "Preparative and Exploratory Carbohydrate Chemistry University of Montreal | Publication | 1974-10-01 | | | Stereoselective Quaternary Center Construction via Atom-Transfer Radical Cyclization using Silicon Tethers on Acyclic Precursors University of Montreal | Publication | 2009-07-01 | | | Phenylselenoethers as Precursors of Acyclic Free Radicals: Creating Tertiary and Quaternary Centers Using Free radical-based Intermediates University of Montreal | Publication | 2006-09-01 | | | Large Scale Preparation of (2S,3S)-N-BOC-3-amino-1,2-Epoxy-4-Phenylbutane : A Key Building Block for HIV-Protease Inhibitors University of Montreal | Publication | 1995-05-01 | | | Synthetic Leukotriene B4 is a Potent Chemotaxin but a Weak Secretagogue for Human PMN University of Montreal | Publication | 1983-02-01 | Rollins T E, Zanolari B, Springer M S, Yvan Guindon, Zamboni R, Lau C K, Rokach J | | A C-Glycoside Route to Leukotrienes University of Montreal | Publication | 1981-03-01 | | | Synthèse stéréocontrôlées des précurseurs chiraux des 11-oxaprostaglandines. A Contribution in the Series Preparitive and Exploratory Carbohydrate Chemistry University of Montreal | Publication | 1974-10-01 | | | Stereocontrolled Synthesis of C1-C17 Fragment of Narasin via a Free Radical-Based Approach University of Montreal | Publication | 2010-01-01 | Brazeau J F*, Guilbault A A*, Kochuparampil J*, Mochirian P*, Yvan Guindon | | Raising the Ceiling of Diastereoselectivity in Hydrogen Transfer on Acyclic Radicals University of Montreal | Publication | 2009-03-01 | Denissova I*, Maretti L, Wilkes B C, Scaiano J C, Yvan Guindon | | Synthesis of N-Glycosides. An Alternative Approach Based on Diastereoselective Base Coupling and SN2 Cyclization University of Montreal | Publication | 2002-01-01 | Gagnon M*, Thumin I ", Chapdelaine D*, Guérin B*, Yvan Guindon | | Diastereoselective Synthesis of 2,3,5-trisubstituted Tetrahydrofurans via Cyclofunctionalization Reactions. Evidence of Stereolectronic Effects University of Montreal | Publication | 2001-12-01 | | | Design and Synthesis of a New Sialyl Lewis X Mimetic : How Selective are the selectin receptors? University of Montreal | Publication | 2001-05-01 | De Vleeschauwer M, Vaillancourt M*, Goudreau N, Gravel D, Yvan Guindon | | Stereocontrol in Radical Processes through the Exocyclic Effect : Dual Role of Triethylboron as Radical Initiator and in Situ Derivatization Agent University of Montreal | Publication | 2001-05-01 | | | The Exo-cyclic Effect : Protecting Group Strategy to Enhance Stereoselectivity in Hydrogen Transfer Reactons of Acyclic Free Radicals University of Montreal | Publication | 1997-12-01 | | | Stereoselective Radical Carbon-Carbon Bond Forming Reactions of B-Alkoxy Esters : Atom and Group Transfer Allylations under Bidendate Chelation Controlled Conditions University of Montreal | Publication | 1996-12-01 | | | Stereoselective Radical Allylations of A-Iodo-B-Alkoxy Esters : Reversal of Facial Selectivity by Lewis Acid Complexation University of Montreal | Publication | 1995-05-01 | Guérin B*, Chabot C*, Mackintosh N*, Ogilvie W W, Yvan Guindon | | A New Approach to Explore the Binding Space of Polysaccharide-based Ligand. Selectin Antagonist University of Montreal | Publication | 2012-12-01 | Calosso M*, Charpentier D*, Vaillancourt M*, Bencheqroun M*, Wilkes B C, Yvan Guindon | | Stereodivergent Synthesis of the C1-C9 Tetrahydropyran Subunit of Zincophorin and Isomers Thereof University of Montreal | Publication | 2012-02-01 | François Godin, Katsouli I*, Fiola-Masson E*, Dhambri S*, Mochirian P*, Yvan Guindon | | A Bidirectional Approach to the Synthesis of Polypropionates Synthesis of C1-C13 Fragment of Zincophorin and Related Isomers University of Montreal | Publication | 2011-10-01 | Mochirian P*, François Godin, Katsoulis I*, Fontaine I*, Brazeau J F*, Yvan Guindon | | Lewis Acids in Diastereoselective Processes involving Acyclic Radicals University of Montreal | Publication | 1996-01-01 | Guérin B*, Rancourt J, Chabot C*, Mackintosh N*, Ogilvie W W, Yvan Guindon | | The Effect of Polar Substituents on the Conformation and Stereochemistry of Enolate Radicals University of Montreal | Publication | 1993-09-01 | Giese B, Damm W, Wetterich F, Zeitz H G, Rancourt J, Yvan Guindon | | Synthesis of Leukotrienes - New Synthesis of Natural Leukotriene A4 University of Montreal | Publication | 1981-01-01 | Rokach J, Young R N, Kakushima M, Lau C K, Seguin R, Frenette R, Yvan Guindon | | Opening of Tartrate Acetals Using Dialkylboron Bromide: Evidence for Stereoselectivity Downstream from Ring Fission University of Montreal | Publication | 2003-01-01 | Ogilvie W W, Bordeleau J, Cui W, Durkin K, Gorys V, Juteau H*, Yoakim C, Yvan Guindon | | Cyclofuntionalization and Free Radical Based Hydrogen Transfer Reactions. An Iterative Reaction Sequence Applied to the Synthesis of the C7, C16 Subunit of Zincophorin University of Montreal | Publication | 2001-08-01 | Murtagh L*, Caron V*, Landry S R*, Jung G, Bencheqroun M*, Faucher A M, Guérin B*, Yvan Guindon | | Role of S-Donation in the Stereocontrol of Hydrogen-Transfer Reactions Involving Acyclic Radicals University of Montreal | Publication | 1995-01-01 | Slassi A*, Rancourt J, Bantie J, Bencheqroun M*, Murtagh L*, Ghiro E, Jung G, Yvan Guindon | | Stereocontrolled Synthesis of Propionate Motifs from L-lactic and L-alanine Aldehydes. A DFT Study of the Hydrogen Transfer Under Endocyclic Control University of Montreal | Publication | 2014-08-01 | François Godin, Duplessis M*, Buonomano C*, Trinh T*, Houde K*, Chapdelaine D*, Rodrigue J*, Boutros A*, Yvan Guindon | | Practical, Stereoselective Synthesis of Palinavir, a Potent HIV Protease Inhibitor University of Montreal | Publication | 1997-05-01 | Beaulieu P L, Lavallée P, Abraham A, Anderson P C, Boucher C, Bousquet Y, Duceppe J S, Gillard J, Gorys V, Grand-Maître C, Grenier L, Yvan Guindon, Guse I, Plamondon L, Soucy F, Valois S, Wernic D | | A Potent Peptidomimetic Inhibitor of HSV Ribonucleotide Reductase with Antiviral Activity in vivo University of Montreal | Publication | 1994-12-01 | Liuzzi M, Déziel R, Moss N, Beaulieu P, Bonneau A M, Bousquet C, Chafouleas J C, Garneau M, Jaramillo J, Krogsrud R L, Lagacé L, McCollum R S, Nawoot S, Yvan Guindon | | Benzoxazolamines and Benzothiazolamines : Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action University of Montreal | Publication | 1994-04-01 | Lazer E S, Miao C K, Wong H C, Sorcek R, Spero D M, Gilman A, Pal K, Behnke M, Graham A G, Watrous J M, Homon C A, Nagel J, Shah A, Farina P R, Adams J, Yvan Guindon |
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